Icahn School of Medicine at Mount Sinai
Public University • US
Showing 14 courses from Icahn School of Medicine at Mount Sinai
Systems Biology and Biotechnology Capstone
Icahn School of Medicine at Mount Sinai (via Coursera)
NOTE: In order to take this course you should have taken and complete the following courses in the Signature Track: Introduction to Systems Biology, Network Analysis in Systems Biology, Dynamical Modeling Methods for Systems Biology, Experimental Methods in SB and Integrated Analysis In Systems Biology
Introduction to Hearing Loss
Icahn School of Medicine at Mount Sinai (via Coursera)
Welcome to Introduction to Hearing Loss Disorders of the ear range from simple, easily treated entities (such as wax or cerumen impaction) to the highly complex (such as permanent hearing loss). Many of these disorders manifest with similar symptoms and may be difficult to differentiate without a basic understanding of the anatomy of the ear and auditory pathway. This course, offered by the Department of Otolaryngology – Head and Neck Surgery at the Icahn School of Medicine at Mount Sinai and New York Eye and Ear Infirmary of Mount Sinai, presents the basic anatomy of the ear from the auricle or outer ear to the brain. The pathophysiology of each type of hearing loss is presented and common pathology in each of the three areas of the ear (outer, middle and inner) are reviewed. Participants will become familiar with the structural and cellular anatomy in each area, as well as the underlying pathophysiology for various disorders. They will also gain an understanding of available treatments for various ear conditions. Week 1: Introduction Week 2: Anatomy and pathophysiology of the auditory pathway (15 min. + quiz) Week 3: Disorders and treatments of the outer ear (15 min. + quiz) Week 4: Disorders and treatments of the middle ear (15 min. + quiz) Week 5: Disorders and treatments of the inner ear (15 min. + quiz) The primary objectives of this course are to: • Recognize the functional and cellular anatomy of the auditory pathway • Understand the types of hearing loss and common causes of each type • Demonstrate familiarity with disorders of the outer, middle and inner ear Those participating in this course have the option to complete the course at no cost or receive the Coursera Signature Track Certificate for $49.95. Course Planners: Lisa Chase Ni-ka Ford Jill Gregory Gale Justin Paul Lawrence Erik Popil Kelly Zerella Amy Zhong Taught By: Maura Cosetti, MD Assistant Professor Otolaryngology - Head and Neck Surgery Icahn School of Medicine at Mount Sin...
Introduction to Systems Biology
Icahn School of Medicine at Mount Sinai (via Coursera)
This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems? The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate “how” cell- level functions arise and “why” mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses.
Experimental Methods in Systems Biology
Icahn School of Medicine at Mount Sinai (via Coursera)
Learn about the technologies underlying experimentation used in systems biology, with particular focus on RNA sequencing, mass spec-based proteomics, flow/mass cytometry and live-cell imaging. A key driver of the systems biology field is the technology allowing us to delve deeper and wider into how cells respond to experimental perturbations. This in turns allows us to build more detailed quantitative models of cellular function, which can give important insight into applications ranging from biotechnology to human disease. This course gives a broad overview of a variety of current experimental techniques used in modern systems biology, with focus on obtaining the quantitative data needed for computational modeling purposes in downstream analyses. We dive deeply into four technologies in particular, mRNA sequencing, mass spectrometry-based proteomics, flow/mass cytometry, and live-cell imaging. These techniques are often used in systems biology and range from genome-wide coverage to single molecule coverage, millions of cells to single cells, and single time points to frequently sampled time courses. We present not only the theoretical background upon which these technologies work, but also enter real wet lab environments to provide instruction on how these techniques are performed in practice, and how resultant data are analyzed for quality and content.
Health Care IT: Challenges and Opportunities
Icahn School of Medicine at Mount Sinai (via Coursera)
A strong argument can be made that the health care field is one of the most information-intensive sectors in the U.S. economy and avoidance of the rapid advances in information technology is no longer an option. Consequently, the study of health care information technology and systems has become central to health care delivery effectiveness. This course covers the modern application of information technology that is critical to supporting the vision and operational knowledge of the health care leaders in managing the health care organization. Heath care decision-makers have to meet head-on the dynamic challenges of health care delivery quality, cost, access, and regulatory control. Additionally, this course integrates the Healthcare Information System as integral to the Quality Assurance Tracking Programs including measurement of systems inputs, processes, and outputs with special emphasis on systems outcomes research and organizational accountability to its various stakeholders, not the least of which are government regulators.
Voice Disorders: What Patients and Professionals Need to Know
Icahn School of Medicine at Mount Sinai (via Coursera)
Welcome to Voice Disorders: What Patients and Professionals Need to Know Knowledge regarding vocal production physiology and management options for voice disorders have experienced rapid growth over the past 40 years. This growth has resulted in a knowledge gap amongst patients and practitioners. Entirely new subspecialties of laryngology under otolaryngology and vocology under speech-language pathology have developed in response to this gap. This MOOC (Massive Open Online Course) is designed to educated patients, allied healthcare providers, vocal trainers/coaches, general medical practitioners and otolaryngologists. Participants will be exposed to current concepts on the physiology of voice production. These physiologic principles will be applied to speaking and performance voice production styles. Building on the knowledge of efficient voice production methods, participants will learn how vocal inefficiencies can lead to the development of voice disorders. Finally, behavioral, medical and surgical management options and indications will be presented. The course has been divided into five modules, each of which is followed by multiple choice questions: Week 1 - CME Information, Accreditation and Introduction (2 min) Week 2 - Module 1: Basic Anatomy and Physiology of the Speaking and Singing Voice (29 min. + quiz) Week 3 - Module 2: Applied Physiology (Function) (20 min. + quiz) Week 4 - Module 3: Changes in Vocal Effort and Quality (20 min. + quiz) Week 5 - Module 4: Principles of Voice Evaluation and Examination (17 min. + quiz) Week 6 - Module 5: Medical or Surgical Intervention (33 min. + quiz) Note: This course is no longer available for CME Credit. Please review the CME Information and Accreditation prior to proceeding with the course modules. Release Date: November 29, 2017 Expiration Date: November 29, 2019 Estimated Time to Complete: 3 hours CME Fee: $30 CME Credits Offered: 3.0 CME Reviewer: Marita S. Teng, MD How to Receive CME Cre...
Transgender Medicine for General Medical Providers
Icahn School of Medicine at Mount Sinai (via Coursera)
The course is a comprehensive set of didactic lectures surveying fundamentals of transgender medical and surgical treatment. The material is meant to provide the student with core knowledge that is essential for current primary care providers caring for transgender patients. There are 10 modules led by the expert clinical faculty from the pioneering Center for Transgender Medicine and Surgery, located within the Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai in New York City. The course begins with an introduction to frame the sea change that has taken place in the current medical practice of transgender health care. Subsequent modules allow individuals to learn key elements necessary to provide quality transgender medical care. As a whole, the modules provide an opportunity to develop a knowledgeable approach to behavioral health, primary care, hormone therapy, and the surgical options. Module 1: Introduction - Joshua D Safer Module 2: Making the Determination - Hansel Arroyo Module 3: Primary Care for Transgender Women - Zil Goldstein Module 4: Primary Care for Transgender Men - Zil Goldstein Module 5: What are the Essential Strategies to Transgender Hormone Therapy? - Joshua D Safer Module 6: Initiation and Maintenance of Hormones for the Trans Masculine Patient - Joshua D Safer Module 7: Initiation and Maintenance of Hormones for the Trans Feminine Patient -Joshua D Safer Module 8: Transgender Surgery: Chest & Face - Bella K Avanessian Module 9: Transmasculine Genital Surgery - Bella K Avanessian Module 10: Transfeminine Genital Surgery - Bella K Avanessian
Integrated Analysis in Systems Biology
Icahn School of Medicine at Mount Sinai (via Coursera)
This course will focus on developing integrative skills through directed reading and analysis of the current primary literature to enable the student to develop the capstone project as the overall final exam for the specialization in systems biology.
HPV-Associated Oral and Throat Cancer: What You Need to Know
Icahn School of Medicine at Mount Sinai (via Coursera)
Welcome to HPV-Associated Oral and Throat Cancers: What You Need to Know This course, offered by the Department of Otolaryngology – Head and Neck Surgery at the Icahn School of Medicine at Mount Sinai, is designed to inform primary care physicians and otolaryngologists (general and head and neck surgeons), as well as medical students, residents, nurses, physician assistants, medical assistants, about HPV-associated oral and throat cancers. It is also applicable to individuals who wish to broaden their knowledge and vernacular about this disease process, especially those who may have been diagnosed with HPV and/or HPV-associated oropharyngeal cancers. The course has been divided into four modules, each of which is followed by multiple choice questions to help attendees further understand this condition: Week 1 - CME Information, Accreditation and Introduction (2 min) Week 2 - Module 1: HPV-associated Throat Cancer: An Epidemic (11 min. + quiz) Week 3 - Module 2: HPV Risk Factors and Clinical Presentation (10 min. + quiz) Week 4 - Module 3: Management of HPV-associated Oropharyngeal Cancer (13 min. + quiz) Week 5 - Module 4: Prevention, Vaccination, and the Horizon (10 min. + quiz) The primary objective of this course is to provide physicians with a thorough understanding of how to better diagnose and treat patients who have HPV-related oral and throat cancers. Note: This course is no longer available for CME Credit. Please review the CME Information and Accreditation prior to proceeding with the course modules. Release Date: February 4, 2019 Expiration Date: February 4, 2021 Estimated Time to Complete: 1 hour CME Fee: $30 CME Credits Offered: 1.0 CME Reviewer: Marita S. Teng, MD How to Receive CME Credit: For physicians who are interested in earning CME credits and other allied health professions who wish to receive a Verification of Attendance certificate, you must: a. Complete Signature Track (details to follow after enrolling in this course) ...
Big Data Science with the BD2K-LINCS Data Coordination and Integration Center
Icahn School of Medicine at Mount Sinai (via Coursera)
The Library of Integrative Network-based Cellular Signatures (LINCS) was an NIH Common Fund program that lasted for 10 years from 2012-2021. The idea behind the LINCS program was to perturb different types of human cells with many different types of perturbations such as drugs and other small molecules, genetic manipulations such as single gene knockdown, knockout, or overexpression, manipulation of the extracellular microenvironment conditions, for example, growing cells on different surfaces, and more. These perturbations are applied to various types of human cells including cancer cell lines or induced pluripotent stem cells (iPSCs) from patients, differentiated into various lineages such as neurons or cardiomyocytes. Then, to better understand the molecular networks that are affected by these perturbations, changes in levels of many different molecules within the human cells were measured including: mRNAs, proteins, and metabolites, as well as cellular phenotypic changes such as cell morphology. The BD2K-LINCS Data Coordination and Integration Center (DCIC) was commissioned to organize, analyze, visualize, and integrate this data with other publicly available relevant resources. In this course, we introduce the LINCS DCIC and the various Data and Signature Generation Centers (DSGCs) that collected data for LINCS. We then cover the LINCS metadata, and how the metadata is linked to ontologies and dictionaries. We then present the data processing and data normalization methods used to clean and harmonize the LINCS data. This follows by discussions about how the LINCS data is served with RESTful APIs. Most importantly, the course covers computational bioinformatics methods that can be applied to other multi-omics datasets and projects including dimensionality reduction, clustering, gene-set enrichment analysis, interactive data visualization, and supervised learning. Finally, we introduce crowdsourcing/citizen-science projects where students can work together in tea...
Responsible Medication Prescribing for Older Adults
Icahn School of Medicine at Mount Sinai (via Coursera)
Older adults are more likely to consume more prescription and non-prescription medications, and this can place them at high risk for unintended harmful effects. An important component of the care of older adults relates to medication management. This course offers healthcare professionals and learners a comprehensive understanding of the physiological changes that occur with aging and their implications on medication management. It aims to equip participants with essential knowledge and skills to ensure safe and appropriate prescribing for older adults. Through a series of engaging presentations, attendees will explore key concepts in pharmacology, evidence-based frameworks, and interdisciplinary practical strategies to optimize prescribing practices and enhance patient care across the continuum of care sites.
Acute and Chronic Rhinosinusitis: A Comprehensive Review
Icahn School of Medicine at Mount Sinai (via Coursera)
Welcome to Acute and Chronic Rhinosinusitis: A Comprehensive Review This course, offered by the Department of Otolaryngology – Head and Neck Surgery at the Icahn School of Medicine at Mount Sinai, is designed to inform primary care physicians and general otolaryngologists, as well as nurses, physician assistants and medical assistants, about the differences between acute and chronic rhinosinusitis and how to distinguish and treat them. It is also applicable to individuals who wish to broaden their knowledge and vernacular about this disease process, especially those who may suffer from this condition. The course has been divided into four modules, each of which is followed by multiple choice questions to help attendees further understand this condition: Week 1 - CME Information, Accreditation and Introduction Week 2 - Module 1: Normal Sinus Anatomy and Function (15 min. + quiz) Week 3 - Module 2: Acute Rhinosinusitis: Diagnosis and Treatment (17 min. + quiz) Week 4 - Module 3: Chronic Rhinoinusitis: Diagnosis and Treatment (18 min. + quiz) Week 5 - Module 4: The Role of Surgery for Sinusitis and Activity Evaluation (36 min. + 2 quizzes) The primary objective of this course is to provide physicians with a thorough understanding of how to better diagnose and treat patients who suffer from acute and chronic rhinosinusitis. Note: This course is no longer available for CME Credit. Please review the CME Information and Accreditation prior to proceeding with the course modules. Release Date: January 16, 2018 Expiration Date: January 16, 2020 Estimated Time to Complete: One Hour and Forty Five Minutes CME Fee: $30.00 CME Credits Offered: 1.75 CME Reviewer: Marita S. Teng, MD How to Receive CME Credit: For physicians who are interested in earning CME credits and other allied health professions who wish to receive a Verification of Attendance certificate, you must: a. Complete Signature Track (details to follow after enrolling in this course) b. Complete registrati...
Dynamical Modeling Methods for Systems Biology
Icahn School of Medicine at Mount Sinai (via Coursera)
An introduction to dynamical modeling techniques used in contemporary Systems Biology research. We take a case-based approach to teach contemporary mathematical modeling techniques. The course is appropriate for advanced undergraduates and beginning graduate students. Lectures provide biological background and describe the development of both classical mathematical models and more recent representations of biological processes. The course will be useful for students who plan to use experimental techniques as their approach in the laboratory and employ computational modeling as a tool to draw deeper understanding of experiments. The course should also be valuable as an introductory overview for students planning to conduct original research in modeling biological systems. This course focuses on dynamical modeling techniques used in Systems Biology research. These techniques are based on biological mechanisms, and simulations with these models generate predictions that can subsequently be tested experimentally. These testable predictions frequently provide novel insight into biological processes. The approaches taught here can be grouped into the following categories: 1) ordinary differential equation-based models, 2) partial differential equation-based models, and 3) stochastic models.
Network Analysis in Systems Biology
Icahn School of Medicine at Mount Sinai (via Coursera)
This course introduces data analysis methods used in systems biology, bioinformatics, and systems pharmacology research. The course covers methods to process raw data from genome-wide mRNA expression studies (microarrays and RNA-seq) including data normalization, clustering, dimensionality reduction, differential expression, enrichment analysis, and network construction. The course contains practical tutorials for using several bioinformatics tools and setting up data analysis pipelines, also covering the mathematics behind the methods applied by these tools and workflows. The course is mostly appropriate for beginning graduate students and advanced undergraduates majoring in fields such as biology, statistics, physics, chemistry, computer science, biomedical and electrical engineering. The course should be useful for wet- and dry-lab researchers who encounter large datasets in their own research. The course presents software tools developed by the Ma’ayan Laboratory (http://labs.icahn.mssm.edu/maayanlab/) from the Icahn School of Medicine at Mount Sinai in New York City, but also other freely available data analysis and visualization tools. The overarching goal of the course is to enable students to utilize the methods presented in this course for analyzing their own data for their own projects. For those students that do not work in the field, the course introduces research challenges faced in the fields of computational systems biology and systems pharmacology.